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Heparin, Buy Heparin
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| |  | | Heparin - 5 Vials x 5 ml (5000 IU)Package: 5 Vials x 5 ml (5000 IU)
Usage: Injectable
It is used to stop blood clots forming within the blood vessels
| Price: $79.00
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Heparin, Buy Heparin Online
Brand names: Hep-Pak, Heparin Lock Flush, Hep-Pak CVC, Hep-Lock, Heparin Sodium ADD-Vantage.
Generic Name: heparin (HEP a rin).
Heparin belongs to the medication classes known as anticoagulants. A question appears: what is the function of an anticoagulant? The function of anticoagulants is discontinuing coagulation; in other words, anticoagulant stops blood from clotting. But it is not able to diminish the volume of the blood clots which have been already developed. It is essentially to mention that this medicine has other functions too. The most significant purpose of this medicine is to fight against invading bacteria and other foreign compouns.
This drug is administrated by injection into a vein or under the skin (subcutaneously). It should not be injected into a muscle.
Structure of Heparin
Heparin is composed of a variably sulfated repeating disaccharide unit. The most common disaccharide unit is composed of a 2-O-sulfatediduronic acid and 6-O-sulfated, N-sulfated glucosamine, IdoA(2S)-GlcNS(6S). For example, it makes up 85% of heparins from beef lung and about 75% of those from porcine intestinal mucosa.
The major sugars which occur in this product are listed below:
α-L-iduronic acid 2-sulfate;
2-deoxy-2¬sulfamino-α-D-glucose 6-sulfate;
β-D-glucuronic acid;
2-acetamido-2-deoxy-α-D¬glucose;
α-L-iduronic acid.
These sugars are present in decreasing amounts, as a regular in the order (2) > (1) > (4) > (3) > (5). Heparin is strongly acidic due to its content of covalently linked sulfate and carboxylic acid groups.
Mechanism of action of heparin
It has been already mentioned that this preparation stops blood from clotting. How does it act? It neutralizes thrombin. In order to inactivate thrombin this drug links itself to the coagulation enzyme and antithrobin. The activated antithrombin neutralizes thrombin and other proteases caused blood clotting. Thus, wee see that antithrombin prevents coagulation by neutralizing proteins that take part in the coagulation cascade.
Administration of Heparin
Heparin is taken in case of dialysis, during extracorporeal circulation ardiopulmonary bypass for heart surgery.
This preparation is used to treat patients with following diseases:
peripheral occlusive disease;
thromboprophylaxis;
acute coronary syndrome;
atrial fibrillation;
deep-vein thrombosis and pulmonary embolism.
Heparin dosage
The recommended dosage of heparin depends on some aspects. The dosage is henges on the coagulation test results. These tests must be performed enough often. The determination of coagulation time depends on specific factors. If heparin is administrated by continous intravenous infusion, the coagulation tests should be done approximately every four hours in the early stages of treatment. If the drug is administered intermittently by intravenous injection, coagulation tests have to be done before every injection during the early stages of treatment.
In case of deep vein Thrombosis – Prophylaxis common the prescribed dose is 5000 units subcutaneously every 8 to 12 hours.
Usual dosage for anticoagulation during pregnancy is 5000 units under the skin each 12 hours.
Usual adult dose for thrombotic disorder is100 units/mL every 6 to 8 hours for PVC catheters and peripheral heparin locks. But if stagnant blood is observed in catheter after it was utilized for drug or blood administration, it is necessary to add flushes. The dosage for babies who have got thrombotic disorder is 10 units each 6 to 8 hours. Child dose in case mentioned above is 100 units/mL every 6 to 8 hours. Additional flushes should be administrated when stagnant blood is noticed in catheter, after catheter is utilized for drug or blood administration.
If a patient has got a severe pulmonary embolism, the starting dosage can be an IV bolus of 10,000 units which are followed by 1500 units per hour.
Possible adverse reactions of heparin
Heparin, as every drug may lead to adverse results. Many patients administrating this medicine do not have severe adverse consequences. Some general unwanted results of this product are following: swelling at injection site, bone ache, easily broken bones. Pain and loss of feeling in the arms and legs, change in color of the arms and legs, chest pain, difficult breathing, confusion, weakness on one side of the body, slurred speech, vision changes.
Heparin may cause some other unwanted consequences: signs of severe bleeding, including unusual pain, swelling, discomfort, long-term bleeding from cuts, persistent nosebleeds, unusually heavy and long-term menstrual periods, unusual easy bruising, dark urine, black stools, serious headache, unusual dizziness.
Severe allergic reactions were registered rarely, but sometimes they can occur. If you administrate this medicine and notice such symptoms as rash, itching, swelling, serious dizziness, difficult breathing and others, consult your prescriber.
There are such unwanted effects which are caused in case of long-term Heparin administration; others may be results of a systematic using of this medicine. For example, osteoporosis may be caused by long-term utilizing of high doses of heparin, cutaneous necrosis has been reported after systemic utilizing; inhibition of aldosterone synthesis, delayed transient alopecia, priapism, and rebound hyperlipemia on discontinuation of this medication have also been noticed.
Important increasing of aminotransferase grades have occurred in a high percentage of patients and healthy people who have administrated heparin.
Coumadin and Heparin
Coumadin and Heparin are anticoagulants, so they both stop blood from clotting. They are administrated to cure such conditions as embolism and thrombosis. Even though they sound similar, coumadin and heparin have got a lot of differences. As for adninstrating them, coumadin is used orally, heparin is usedin a form of injection. Coumadin should not be utilized during pregnancy, heparin may be administrated by pregnant women. Coumadin and heparin may cause excessive bleeding which may be life-threatening.
Heparin recall
Firstly, let metion what medication recalls are. Medication recalls are such acts which are perfomed in order to remove some medicines from the market.
As for Heparin, the most of recalls were in 2008 as a result of unwanted reactions of heparin which was manufactured in China.
But there were no any recalls related to heparin which was prodused by B. Braun Medical Inc. B.Braun producer advices to discontinue heparin utilizing and consult your doctor, if any undesirable reactions are noticed.
Heparin-induced thrombocytopenia
Heparin-induced thrombocytopenia (HIT) is a form of thrombocytopenia which was caused by using of heparin. Thus, it is a adverse effect which was produced by heparin administration. There are two types of Hit: type 1 and type 2. HIT type 2 is a more severe unwanted consequence than HIT type 2. HIT type 2 may be a life-threatening aspect. In order to confirm that a person has HIT, he should perform certain laboratory tests.
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